CDKN2A is a tumor suppressor gene comprised of 4 exons (1a, 1b, 2, and 3) that encode two tumor suppressor proteins, p16 (1a, 2, and 3) and p14 (exons 1b, 2, and 3), via differential splicing and alternative reading frames (PMID: 26488006). p14 is a stabilizer of the tumor suppressor protein p53, and p16 promotes the arrest of the cell cycle in


CDKN2A Lifetime Cancer Risks (%)* * The above cancer risks represent the typical range for individuals with a mutation in this gene. If available, cancer risks specific to the mutation found in you will be provided in your results report.

Independently reviewed in 6… 2016-06-01 BackgroundThe diagnosis of malignant pleural mesothelioma (MPM) can be difficult, in part due to the difficulty in distinguishing between MPM and reactive mesothelial hyperplasia (RMH). The tumor suppressor gene, CDKN2A, is frequently silenced by epigenetic mechanisms in many cancers; in the case of MPM it is mostly silenced via genomic deletion. 2016-06-01 Analysis of CDKN2A, CDKN2B, CDKN2C, and Cyclin Ds Gene Status in Hepatoblastoma ACHILLE IOLASCON,1 LUCIA GIORDANI,1 ARCANGELA MORETTI,1 GIUSEPPE BASSO,2 ADRIANA BORRIELLO,3 AND FULVIO DELLA RAGIONE3 The status and the expression of cyclin-dependent kinase inhibitor A (CDKN2A) family genes, named CDKN2A, cancers Review KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer Jonas Cicenas 1,2,3,*, Kotryna Kvederaviciute 4, Ingrida Meskinyte 5, Edita Meskinyte-Kausiliene 6, Aiste Skeberdyte 7 and Jonas Cicenas Jr. 8 1 Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, Länggassstrasse 122, 3012 Bern, Switzerland Sarcomas are a rare, heterogeneous group of tumors with variable tendencies for aggressive behavior. Molecular markers for prognosis are needed to risk stratify patients and identify those who might benefit from more intensive therapeutic strategies. We analyzed somatic tumor genomic profiles and clinical outcomes of 152 soft tissue (STS) and bone sarcoma (BS) patients sequenced at Stanford CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3.


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The CDKN2A gene is associated with autosomal dominant melanoma-pancreatic cancer syndrome (PMID: 18178632, 26892650) and also with a rare, emerging syndrome called melanoma-neural system tumor (melanoma-NST) syndrome (PMID: 9622062, 19095153, 11433531, 26876133). The CDKN2A gene encodes two distinct proteins: p16INK4a and p14ARF. Rabbit monoclonal [EP435Y-129R] to CDKN2A/p16INK4a - BSA and Azide free Background The most recent cIMPACT-NOW update highlighted the homozygous deletion of the Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) gene as a clinically important molecular alteration in IDH-mutant glioma. Correspondingly, we systematically reviewed the contemporary literature to affirm the contemporary stance of the literature on the prognostic significance of this alteration in this The CDKN2A transcripts were notably downregulated in patients with genomic depletion. We further demonstrated that ectopic CDKN2A expression remarkably inhibited cell proliferation and viability in lung cancer cells, while siRNA‐mediated CDKN2A knockdown greatly promoted cell proliferation Pancreatic cancer is a disease that has a very high fatality rate and one of the highest mortality ratios among all major cancers, remaining the fourth leading cause of cancer-related deaths in developed countries.

CDKN2A Mutation Analyses. Melanoma family members were invited to undergo germline CDKN2A mutation analysis for the purpose of study. Procedures used for DNA isolation from peripheral blood mononuclear cells, polymerase chain reaction (PCR) of CDKN2A exons, and direct sequencing of PCR products have been described previously ().

CDKN2A has 10,679 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, … 2020-11-20 It has been reported that CDKN2A and CDKN2B are frequently inactivated in various hematologic malignancies. 1,4 Loss of heterozygosity (LOH) of chromosome arm 9p, including the CDKN2A locus, is one of the most frequent genetic events in childhood acute lymphoblastic leukemia (ALL), suggesting inactivation of the second allele or, possibly, haploinsufficiency. 5-8 Haploinsufficiency of a tumor CDKN2A expression was correlated with an inferior rate of recurrent disease (p = 0.02). In high-risk HPV DNA+ vulvar squamous cell carcinomas patients with CDKN2A- carcinomas showed a significantly worse overall survival than women with CDKN2A+ tumors (56% vs.100%, p = 0.003).


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Q50fs has not been characterized, however, due to the effects of other truncation mutations downstream of Q50 ( PMID: 9053859 , PMID: 8668202 ), is The association between cutaneous and uveal melanomas in some families suggests that mutations in CDKN2A may account for a proportion of uveal melanomas.


2020-06-27 · CDKN2A mediates the AKT–mTOR signaling pathway by suppressing lactate dehydrogenase (LDHA). Taken together, our data revealed that CDKN2A can be applied as a therapeutic target for the treatment of cervical cancer in future. CDKN2A inhibits cell proliferation and invasion in cervical cancer through LDHA-mediated AKT–mTOR pathway.
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CDKN2A Mutations. Cancer Risk and Management Recommendations. Cancer Type.

CDKN2A Lifetime Cancer Risks (%)* * The above cancer risks represent the typical range for individuals with a mutation in this gene.
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The ZytoLight ® SPEC CDKN2A/CEN 9 Dual Color Probe is designed for the detection of p16 deletions by Fluorescence in situ Hybridization (FISH) frequently observed in most tumor cell lines as well as in primary human malignancies. The p16 gene, often referred to as CDKN2A or INK4a/ARF, is located in the chromosomal region 9p21.3. p16 has been identified as a major susceptibility gene for melanoma.

CDKN2A loss has been shown to be a significant event in a number of cancer types. While no targeted therapeutic has been engaged in clinical trials, the prognostic impact … 2019-08-31 CDKN2A (ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf) protein expression summary.